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doi:10.1016/j.biotechadv.2016.11.008
Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Elsevier Inc
Biotechnology Advances , Accepted manuscript. doi:10.1016/j.biotechadv.2016.11.008
Henning Gram Hansen
Nuša Pristovšek
Helene Faustrup Kildegaard
Gyun Min Lee
Cell engineering
Chinese hamster ovary (CHO) cells
Ectopic expression
Endoplasmic reticulum
ER stress
Gene dosage
Product quality
Recombinant protein production
Secretion bottleneck
Specific productivity
P
0734-9750
http://dx.doi.org/10.1016/j.biotechadv.2016.11.008
10.1016/j.biotechadv.2016.11.008
© 2016 Elsevier Inc. All rights reserved.
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