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/Subject (The invention relates to methods for the global and specific isolation and characterization of the in vivo RNA-Binding Proteome \(RBPome\) present in a cell. The method is performed on cells that have been exposed to UV-light that serves to selectively cross-link cellular RNAs to their associated protein partners under physiological conditions. The method employs RNA splint-mediated ligation to RNA adapters, to selectively isolate cellular RNAs and their associated protein partners, and purification steps that ensure a higher yield and specificity of proteins considered as RBPs. [image])
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"EP3296397"; "EP 3296397"; "C12N 15/10"; "REV-CLIP, A NEW APPROACH TO IDENTIFY PROTEINS INTERACTING WITH RNA"
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EP-3296397-A1-20180321
The invention relates to methods for the global and specific isolation and characterization of the in vivo RNA-Binding Proteome (RBPome) present in a cell. The method is performed on cells that have been exposed to UV-light that serves to selectively cross-link cellular RNAs to their associated protein partners under physiological conditions. The method employs RNA splint-mediated ligation to RNA adapters, to selectively isolate cellular RNAs and their associated protein partners, and purification steps that ensure a higher yield and specificity of proteins considered as RBPs. [image]
The invention relates to methods for the global and specific isolation and characterization of the in vivo RNA-Binding Proteome (RBPome) present in a cell. The method is performed on cells that have been exposed to UV-light that serves to selectively cross-link cellular RNAs to their associated protein partners under physiological conditions. The method employs RNA splint-mediated ligation to RNA adapters, to selectively isolate cellular RNAs and their associated protein partners, and purification steps that ensure a higher yield and specificity of proteins considered as RBPs. [image]
en
European Patent Office
EP3296397
EP 3296397
C12N 15/10
REV-CLIP, A NEW APPROACH TO IDENTIFY PROTEINS INTERACTING WITH RNA
REV-CLIP, A NEW APPROACH TO IDENTIFY PROTEINS INTERACTING WITH RNA - European Patent Office - EP 3296397 A1
REV-CLIP, A NEW APPROACH TO IDENTIFY PROTEINS INTERACTING WITH RNA - European Patent Office - EP 3296397 A1
EUROPEAN PATENT APPLICATION
1
B
40
EP
3296397
A1
2018-03-21
16189688.1
2016-09-20
C12N 15/10 20060101AFI20161118BHEP
Danmarks Tekniske Universitet
MULLER, Sébastien
WORKMAN, Christopher
Guardian
IP Consulting I/S
REV-CLIP, A NEW APPROACH TO IDENTIFY PROTEINS INTERACTING WITH RNA
REV-CLIP, EIN NEUER ANSATZ ZUM IDENTIFIZIEREN VON MIT RNA INTERAGIERENDEN PROTEINEN
REV-CLIP, A NEW APPROACH TO IDENTIFY PROTEINS INTERACTING WITH RNA
REV-CLIP, UNE NOUVELLE APPROCHE POUR IDENTIFIER DES PROTÉINES QUI INTERAGISSENT AVEC L'ARN
The invention relates to methods for the global and specific isolation and characterization of the in vivo RNA-Binding Proteome (RBPome) present in a cell. The method is performed on cells that have been exposed to UV-light that serves to selectively cross-link cellular RNAs to their associated protein partners under physiological conditions. The method employs RNA splint-mediated ligation to RNA adapters, to selectively isolate cellular RNAs and their associated protein partners, and purification steps that ensure a higher yield and specificity of proteins considered as RBPs. [image]
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