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A computer-simulated mechanism of familial Alzheimer’s disease: Mutations enhance thermal dynamics and favor looser substrate-binding to γ-secretase
Budheswar Dehury
Arun K. Somavarupu
Kasper P. Kepp
γ-secretase
Alzheimer’s disease
presenilin
mutation
molecular dynamics
Journal of Structural Biology, Journal Pre-proof, 107648. doi:10.1016/j.jsb.2020.107648
Elsevier Inc.
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Journal of Structural Biology
© 2020 Elsevier Inc. All rights reserved.
1047-8477
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